What Is Selank?
Research Use Only: Selank is intended strictly for in-vitro laboratory research purposes only. Not for human consumption, medical treatment, or veterinary use. Read our full disclaimer.
What Is Selank?
Selank is a synthetic heptapeptide analogue of the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg), extended with a Pro-Gly-Pro sequence to improve metabolic stability. In laboratory research, Selank is studied for its interactions with GABAergic signalling pathways, BDNF expression modulation and anxiolytic-related mechanisms in neuronal cell models and in vivo experimental systems.
Mechanism of Action
Selank's mechanism in laboratory models involves modulation of GABAergic neurotransmission and influence on BDNF expression in neuronal systems. Unlike classical benzodiazepines, Selank does not bind directly to GABA-A receptor benzodiazepine sites but appears to modulate GABAergic tone through indirect mechanisms studied in experimental neuronal models.
GABAergic Modulation
Laboratory studies examine Selank's effects on GABA-A receptor function and GABAergic neurotransmission in neuronal cell models. Its anxiolytic-related profile in experimental systems is associated with GABAergic pathway modulation without direct benzodiazepine site binding, making it a mechanistically distinct tool compound for neuropeptide research.
BDNF Expression
Selank has been studied for its effects on brain-derived neurotrophic factor (BDNF) expression in neuronal models. Laboratory investigations examine how Selank influences BDNF mRNA and protein levels, and the downstream effects on neuronal survival, plasticity-related signalling and synaptic protein expression in vitro.
Research Applications
Anxiolytic Pathway Research
Selank is used in laboratory models to study anxiolytic-related signalling mechanisms, particularly GABAergic pathway modulation and its relationship to anxiety-related behavioural endpoints in experimental systems. It provides a mechanistically distinct tool from classical benzodiazepines for studying GABAergic neurotransmission.
Neuropeptide Research
As a synthetic neuropeptide analogue, Selank is used to study how small peptides interact with neuronal signalling systems. Laboratory investigations examine receptor interactions, signal transduction and gene expression changes in neuronal cell models following Selank treatment.
BDNF and Neurotrophin Research
Selank's effects on BDNF expression make it relevant to research examining neurotrophin signalling, synaptic plasticity-related mechanisms and neuroprotective pathway modulation in vitro. It is used alongside other BDNF-modulating compounds such as Semax in comparative neuropeptide studies.
Structural Characteristics
Selank has the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (MW approximately 751 Da). The Pro-Gly-Pro C-terminal extension relative to tuftsin confers resistance to enzymatic degradation, improving stability in experimental systems. Its heptapeptide structure is small enough for straightforward cell culture work while retaining the receptor interaction profile of the parent tuftsin sequence.
Storage & Handling
Store lyophilised Selank at -20°C, protected from light and moisture. Reconstitute with sterile water or appropriate buffer prior to use. Use the Concentration Calculator to determine the correct volume for your target concentration. Follow institutional laboratory protocols for handling and disposal.
Quality & Documentation
Solatide Biosciences Selank is independently third-party tested to >=99% purity, verified by HPLC and mass spectrometry. A Certificate of Analysis is available on the product page.
Related Compounds
Research Use Only: All compounds are manufactured for in-vitro laboratory research and are not intended for human consumption, medical use, or veterinary applications. Full disclaimer.