What Is Tesamorelin?
Research Use Only: Tesamorelin is intended strictly for in-vitro laboratory research purposes only. Not for human consumption, medical treatment, or veterinary use. Read our full disclaimer.
What Is Tesamorelin?
Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) used in laboratory research to investigate growth hormone secretion, hypothalamic-pituitary signalling and metabolic regulation in experimental models.
Mechanism of Action
Tesamorelin binds to GHRH receptors on pituitary somatotroph cells, stimulating the synthesis and pulsatile release of growth hormone (GH). As a stabilised GHRH analogue, it retains the full 44-amino-acid sequence of endogenous GHRH with a trans-3-hexenoic acid modification that confers resistance to dipeptidyl peptidase IV (DPP-IV) degradation, extending its activity in experimental settings.
Growth Hormone Axis
In laboratory models, Tesamorelin-induced GH release activates downstream IGF-1 production in the liver, enabling researchers to study the GH/IGF-1 axis and its role in anabolic signalling, lipid metabolism and body composition regulation.
Research Applications
Visceral Adipose Tissue Research
Tesamorelin is studied in the context of visceral adipose tissue (VAT) reduction in laboratory models. Researchers use it to investigate the relationship between GH secretion, lipolysis and central adiposity in controlled experimental settings.
Metabolic Signalling
Laboratory investigations employ Tesamorelin to study glucose homeostasis, insulin sensitivity and lipid processing as downstream effects of GH axis activation. It is relevant to research into metabolic syndrome and related pathway dysregulation.
Hypothalamic-Pituitary Research
As a GHRH receptor agonist, Tesamorelin is a useful tool compound for studying hypothalamic-pituitary axis function, GH pulse dynamics and neuroendocrine regulation in vitro.
Structural Characteristics
Tesamorelin consists of the full 44-amino-acid sequence of human GHRH(1-44) conjugated to a trans-3-hexenoic acid group at the N-terminus. This modification stabilises the peptide against enzymatic degradation while preserving receptor binding affinity and biological activity in experimental models.
Storage & Handling
Store lyophilised Tesamorelin at -20°C or -80°C, protected from light and moisture. Reconstitute with bacteriostatic water prior to use. Use the Concentration Calculator to determine the correct volume for your target concentration. Follow institutional laboratory protocols for handling and disposal.
Quality & Documentation
Solatide Biosciences Tesamorelin is independently third-party tested to >=99% purity, verified by HPLC and mass spectrometry. A Certificate of Analysis is available on the product page.
Related Compounds
Research Use Only: All compounds are manufactured for in-vitro laboratory research and are not intended for human consumption, medical use, or veterinary applications. Full disclaimer.